Begin to understand the impact of psychedelics through our reports. Covering them from different topics (e.g. depression), compounds (e.g. LSD), and countries (e.g. Switzerland), we will help you understand and take action in this fast-changing landscape.
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The use of psilocybin predates written history. Its therapeutic potential is not going unnoticed as clinical trials have yielded promising results. Movements to decriminalize psilocybin are well underway in the U.S and further afield.
Known as 'ecstasy' and 'molly,' MDMA is showing serious theraputic potential for the treatment of PTSD and other mental disorders. Clinical trials are in Phase III and many believe MDMA could by FDA approved by 2023.
Fibromyalgia is a condition that causes pain all over the body. Two percent of adults in the US currently suffer from fibromyalgia. Three clinical trials have started this year to investigate the effect of psilocybin on fibromyalgia.
PTSD is generally grouped alongside anxiety disorders given the similar symptomology that is experienced. There is estimated to be over 300 million people living with PTSD globally. MDMA holds significant promise for treating PTSD and is in Phase III of the clinical trial process,
Music has long played a crucial role in psychedelic-assisted therapy (PAT) as it helps evoke emotions, guide patients through their inner journey, and create an optimal therapeutic environment. Modern guidelines recommend using music during PAT, and its importance has been recognized since the early stages of psychedelic research.
Ibogaine is found in several plants native to Western Africa and has a long history of traditional use. Now, researchers are investigating the effectivness of using ibogaine to treat substance use disorders.
2C-X is the name for a group of psychedelic compounds synthesized by Alexander Shulgin. The most common these compounds are 2C-B and 2C-I however, clinical evidence for their therapuetic potential is lacking.
DMT is a powerful yet short-lived hallucinogenic drug that naturally occurs in many plants and animals. It is the main psychoative component of the ayahuasca brew. Some research is underway with this compound.
Mescaline is famously derived from the San Pedro and Peyote cactic. Its healing properties have been known by Indigenous communities in the Americas for thousands of years. This compound is yet to undergo rigorous clincial studies.
There is estimated to be over 150 million people living with some form of substance use disorders worldwide. Thankfully, clinical trials are taking place all over the world using psychedelics like psilocybin, MDMA, ayahuasca, ketamine and ibogaine to treat these disorders and are producing positive results.
The two most common eating disorders are anorexia nervosa and bulimia nervosa, affecting roughly 16 million people globally. Current medications have limited success in treating people with these disorders. Research with psychedelics including MDMA and psilocybin to treat these disorders is underway.
OCD affects an estimated 1-2% of the population and is ranked as one of the 10 most disabling illnesses in terms of lost income and decreased quality of life in tandem with medications like SSRIs is the most common treatment. Phase I studies using psilocybin to treat OCD are underway.
Health behaviour change is the effort to change habits and attitudes to prevent disease. It refers to the motivational, wilful, and action-based processes of stopping health-compromising behaviour in favour of health-enhancing behaviour.
Though not studied nearly enough, some psychedelics (mainly ketamine) are being researched to help those with borderline. One trial is ongoing to study the effects of psilocybin on borderline that co-occurs with depression.
Psychedelics have a long history and have been used for centuries. The knowledge that is possessed by indigenous communities and how they should be compensated is currently a hot topic in psychedelics.
Chemists look closely at molecules and how they react together. This is also the case with psychedelics. This topic report covers how chemists play a role in discovering novel psychedelics, and the new ways of producing them.
Neurocognitive disorders refer to a decrease in mental function due to something other than psychiatric illness. Dementia, Alzheimer's and traumatic brain injury are causes of neurocognitive disorders.
End-of-life anxiety & depression happen to many patients with cancer. In this population, psychedelics research was restarted at the start of this century. Palliative care with psychedelics can help them out tremendously.
In the 70s, psychedelics were used as a relationship therapy tool. MDMA and 2CB were used then to enhance the therapeutic process. Modern research (and therapeutic use) of psychedelics for relationship coaching or therapy is still very limited.
Psychedelics are being investigated for several headache disorders. These include migraines and cluster headaches which are two separate, but both debilitating, headache disorders with different expressions and underlying processes.
If psychedelics are to become medicines at scale, the economics of the treatments do need to work. By work, I mean they will need to be cost-effective to a point that insurers are willing to provide the funds for them. Private (non-medical or non-insured) use will certainly have a place, but the real impact will be realised when psychedelics become part of mainstream healthcare.
It is estimated that chronic pain affects at least 30% of the world’s population. The fallout from the Opioid Epidemic has spurred a new interested in finding more effective treatments for pain management. Some trials using psychedelics like psilocybin to treat phantom-limb pain and cluster headaches are underway.
Nearly 4% of the world's population is affected by one of more than 80 different autoimmune diseases. Many of these diseases have no cure. Researchers believe that psychedelics have anti-inflammatory properties which may be used to treat these disorders.
Anxiety impacts 300 million people. Psychedelics show promise in alleviating symptoms of anxiety. Studies over the last 20 years with LSD, MDMA, ketamine and more psychedelics are paving the way towards psychedelic-assisted therapy for anxiety.
At the simplest level, personality entails the characteristic patterns of thoughts, feelings and behaviours that make a person unique. Personality is ever-changing and it is believed that psychedelics have the ability to influence these changes.
While psychedelics remain illegal in Australia, the countires Health Authorities have recently warmed to the notion of psychedelic therapy, providing a $15 million dollar grant for psychedelic research.
There is estimated to be 45 million people living with some form of bipolar disorder across the globe. No trials have taken place using psychedelics to treat bipolar disorders as researchers are unsure if psychedelics may induce a manic episode in participants.
Autism spectrum disorders are believed to affect 1 in 160 children globally. At present, there are no FDA-approved treatments for autistic adults. There has been little research to date regarding the use of psychedelics to treat autism spectrum disorders, however, one trial using MDMA yielded promising results.
More than 700,000 people die by suicide each year. Suicidality is often linked to a range of mental health disorders including depression and substance use disorders. Ketamine is showing great promise to rapidly alleviate suicidal thoughts, something which is very important when we think of the outcome.
Safety is of the utmost importance when discussing any sort of drug. Not only do scientists have to prove drugs are therapeutically effective, but they must also ensure drugs are safe for human consumption.
Microdosing is the practice of regularly using low doses of psychedelic drugs. This relatively recent phenomenon was made popular through the anecdotal reports of young professionals from all walks of life, taking sub-hallucinogenic doses of psychedelics for a variety of reasons.
About 30% or one in three of those suffering from depression are dealing with so-called treatment-resistant depression (TRD). The name refers to that these patients have tried at least two treatment options, without success. Psychedelics may offer hope to those suffering from TRD.
Can psychedelics aid in creative pursuits? And if they can, how do they help? Creativity and psychedelics have long been a topic of discussion and some research is pointing out how they are intertwined.
Schizophrenia and psychedelics have a long and intertwined history. First psychiatrists took LSD to better understand their patients as they believed that the acute LSD experience mirrored that of their patients. This perspective, of psychedelics as so-called psycho-mimetics persisted for a long time in academia and in the common understanding. Little research has been done on how psychedelics can help those with schizophrenia.
Healthy subjects or health normals is a term used for those who are currently not suffering from a mental health or substance use disorder. In psychedelic research, the term is often used to describe participants in Phase I or Phase II studies who are testing the safety of a treatment.
Psychedelics are allowing neuroscientists to explore the brain like never before.
Reports on Psychedelic: From Addiction to Placebo, and from Anxiety to United States
Psychedelics are becoming serious contenders for the next generation of medicines for mental health. They are being taken through clinical trials, and investment is pouring in on several continents. Our reports cover psychedelics from a variety of angles.
First, we cover them per topic, with a focus on the different mental health disorders for which they can be useful. Second, we investigate the individual compounds and how they are being applied. Third, we inspect the leading countries and report on where they stand with regard to the implementation of psychedelics.