Salvia Divinorum

Salvia divinorum is the most psychoactive compound known to man, working in similar quantities as LSD. Salvinorin A is the principal compound of salvia, a dose of 200 micrograms is enough for psychoactive effects. Salvia divinorum is part of the salvia genus (Lamiaceae) of which mint is also a species. Little is known about the toxicology, adverse events and safety, as little clinical research has been undertaken with salvia. It has psychedelic effects when consumed by chewing, smoking, or being drunk as tea. The chemical structure of salvia is distinct from other psychedelics and it is a potent k-opioid receptor, so not a serotonin receptor agonist. Revixia Life Sciences, an entity of clinical-stage biopharmaceutical company atai Life Sciences, is developing a proprietary formulation of Salvinorin A, RLS-01, as a medication for treatment-resistant depression.

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