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New insights into the clinical and nonclinical effects of psychedelic substances: An integrative review
This review (2022) explores the potential of psychedelics in treating mental health disorders, their short- and long-term effects on recreational users, and the neurological and cognitive processes responsible for their effects using the most up to date research. The positive findings of psilocybin for depression (MDD) and anxiety are highlighted. The mystical experience (MEQ) also plays a large role, but individual differences (for whom does it work) are still not well examined.
Category: Papers
Published: 2022-05-23
The role of extracellular serotonin and MDMA in the sensitizing effects of MDMA
This rodent study (2022) assessed the impact repeated high-dose exposure to MDMA has on markers of serotonin neurotransmission and if this is related to the sensitizing effects of MDMA. The results suggest that the sensitizing effects of MDMA are not due to changes in MDMA-produced synaptic overflow of serotonin but are more likely related to alterations in serotonin receptor mechanisms and/or dopamine neurotransmission.
Category: Papers
Published: 2022-05-23
Incilius alvarius cell-based synthesis of 5-MeO-DMT
This preprint (2022) describes the synthesis of 5-MeO-DMT from a cell line from tissue obtained from the parotoid gland (saliva) of the Sonoran Desert toad (Incilius alvarius). The samples were successfully tested for 5-MeO-DMT but may also contain other 'entourage' compounds. Such methods help to relieve ecological pressures due to the increasing demand for 5-MeO-DMT.
Category: Papers
Published: 2022-05-23
The Psychedelic Integration Scales: Tools for Measuring Psychedelic Integration Behaviors and Experiences
This theory-building paper (2022) describes the development and initial validation of the Integration Engagement Scale (IES) to capture positive behavioural engagement with integration and the Experienced Integration Scale (EIS) to capture internal aspects of feeling integrated following a psychedelic experience. The scales were designed to inform the creation of enhanced integration support and the initial data indicates the scales are valid and reliable.
Category: Papers
Published: 2022-05-23
Cognitive Function Mediates the Anti-suicide Effect of Repeated Intravenous Ketamine in Adult Patients With Suicidal Ideation
This study (n=86) assessed the effects of six infusions of ketamine (35mg/70kg) over 2 weeks on suicidality in patients with depression. Next to the Beck Scale for Suicide Ideation (SSI) and the Montgomery-Asberg Depression Rating Scale (MADRS), the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery was also used. MADRS total score and processing speed (but not other cognitive domains) were significant partial mediators of the association between ketamine treatment and improvements in suicidal ideation.
Category: Papers
Published: 2022-05-23
Traditional Amazonian medicine in addiction treatment: Qualitative results
This pre-print (2022) used open-ended interviews followed by thematic analysis to assess the perspective of patients (n=9) who underwent treatment with ayahuasca in the Takiwasi Center (rehabilitation centre). While the therapeutic effects are supported, the complexities are also discussed.
Category: Papers
Published: 2022-05-23
Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social Function (MASM)
To study the effects of MDMA, compared to a prototypical stimulant, on social motivation, social ability, and neural indices of social function in healthy volunteers.
Category: Trials
Published: 2022-05-23
Psilocybin Versus Ketamine in Treatment-Resistant Depression (PSIKET_001)
e main goal is to compare the antidepressant effects of psilocybin and ketamine in patients with TRD versus the antidepressant inactive substance midazolam.
Category: Trials
Published: 2022-05-23
Acute Dose-dependent Effects of DMT in Healthy Subjects: A Placebo-controlled Cross-over Study (DMT DR)
The present study is a modern randomized cross-over trial, investigating different continuous intravenous DMT dose rates over a broad dose range.
Category: Trials
Published: 2022-05-23
The Effects of Psilocybin on Self-Focus and Self-Related Processing in Treatment Resistant MDD
This open-label fMRI study will assess the effects of a single dose of psilocybin on rumination and the neural correlates of rumination in individuals with treatment-resistant major depressive disorder.
Category: Trials
Published: 2022-05-23

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