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Antidepressant effects of a psychedelic experience in a large prospective naturalistic sample
This survey study (n=302) explored the effects the naturalistic use of psychedelics (i.e. outside of a clinic) has on symptoms of anxiety and depression, and how various pharmacological, extrapharmacological and experience factors related to outcomes. Measurements were taken at four different time points, with reductions in depressive symptoms observed at 2 and 4 weeks. A medicinal motive, previous psychedelic use, drug dose and the type of acute psychedelic experience were all significantly associated with changes in self-rated QIDS-SR-16.
Category: Papers
Published: 2022-08-10
The Watts Connectedness Scale: a new scale for measuring a sense of connectedness to self, others, and world
This paper (2022) uses data from online surveys (n=1,226) and a trial comparing psilocybin to escitalopram (n=52) to validate and test a newly developed scale which measures the effects psychedelics have on feelings of connectedness; the Watts Connected Scale (WCS). The WCS measures connectedness across the three domains of connectedness to self, others, and the world. Factor analysis of all WCS items revealed three main factors with good internal consistency, and the WCS showed good construct validity. Acute measures of ‘mystical experience’, ‘emotional breakthrough’, and ‘communitas’ correlated positively with post-psychedelic changes in connectedness.
Category: Papers
Published: 2022-08-10
Effective connectivity of functionally anticorrelated networks under LSD
This double-blind placebo-controlled study (n=25) assessed whether a change in anticorrelated networks (default mode network (DMN)/salience network (SN)) underlies the peak effects of LSD (100μg) using fMRI. Inhibitory effective connectivity from the SN to DMN became excitatory, and inhibitory effective connectivity from DMN to DAN decreased under the peak effect of LSD suggesting that diminution of the functional anticorrelation between resting state networks that may be a key neural mechanism of LSD and underlie ego dissolution.
Category: Papers
Published: 2022-08-10
Acute and enduring effects of naturalistic psychedelic use among Indigenous peoples in Canada and the United States
This survey study (n=66) explored the effects of naturalistic psychedelic use on recalled psychological distress and trauma symptoms among Indigenous peoples living in the United States and Canada who had experienced racial trauma. The most commonly used psychedelics were psilocybin, MDMA and LSD. Participants recalled experiencing fewer symptoms of depression, anxiety, stress, trauma, symptoms of discrimination, and alcohol use in the 30 days after (vs. before) the psychedelic experience
Category: Papers
Published: 2022-08-10
Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study
This double-blind placebo-controlled study (n=34) explored the effects of microdosing psilocybin (0.5g of dried mushrooms) on subjective experience, behaviour, creativity, perception, cognition, and brain activity. In participants who correctly identified their experimental condition, the acute effects were more intense for the active dose compared to placebo and these effects were accompanied by reduced EEG in the theta band. However, in another blow to microdosing, no evidence was found to support enhanced well-being, creativity and cognitive function. It is likely that expectation underlies the positive effects of microdosing.
Category: Papers
Published: 2022-08-10
Efficacy and Safety of COMP360 Psilocybin Therapy in Anorexia Nervosa: a Proof-of-concept Study
This second trial of COMP360 (psilocybin) by COMPASS will investigate the effectiveness of the psychedelic for anorexia in 60 patients.
Category: Trials
Published: 2022-08-09
Psychedelic Research Links August 2022
This is all the other psychedelic research that came out in August 2022 that we haven't added to our main database.
Category: Links
Published: 2022-08-09
The Psychedelic Handbook
The Psychedelic Handbook by Rick Strassman gives a high-level and expert overview of what psychedelics are, how they work (and for whom we think they can help), and provides practical tips to those who want to use them. Possibly the best intro to psychedelics out there in book form.
Category: Books
Published: 2022-08-08
An Evaluation of Psilocybin's Effect on Cardiac Repolarization
This double-blind placebo-controlled trial (n=36) investigates the effects of psilocybin on heart health (Cardiac Repolarization), the dosing includes one (not defined) extra high dose of psilocybin (supratherapeutic).
Category: Trials
Published: 2022-07-31
Minidosing Lysergic Acid Diethylamide (LSD) for Chronic Cluster Headache
This double-blind, randomised study (n=65) will investigate if every third-day mini-dosing (25μg) of LSD for three weeks (7x dosing) alleviates chronic cluster headaches (CCH).
Category: Trials
Published: 2022-07-31

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