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What happens if psychedelics become a regular part of therapy? In a way, that is what the majority of research on psychedelics is trying to answer. Studies analysing the safety, to mapping out the effectiveness in various domains, including those featured here in February, help us understand psychedelics as medicines.
Category: Overviews
Published: 2024-03-05
This hypothesis paper proposes that psychedelic agents like LSD and psilocybin induce altered states of consciousness by activating the 5-HT2A receptor system, leading to a state of "synthetic surprise." This concept is based on recent understandings of serotonin's role in signaling surprise and is framed within the predictive coding framework, where surprise is seen as a mismatch between expectations and sensory input. The paper suggests that psychedelics disrupt maladaptive patterns by dynamically interacting with top-down expectations and sensory data, with implications for their clinical use, particularly emphasizing their ability to induce surprise to promote therapeutic effects.
Category: Papers
Published: 2024-03-05
This machine learning study (n=16) examines baseline resting-state functional connectivity (FC) measured with fMRI as a predictor of symptom severity in psilocybin-assisted therapy for treatment-resistant depression (TRD). Results show that FC of visual, default mode, and executive networks predicted early symptom improvement, with the salience network predicting responders up to 24 weeks after treatment.
Category: Papers
Published: 2024-03-05
This computational study investigates the membrane permeability of 12 selected tryptamines, aiming to elucidate the impact of various structural modifications on their permeation behaviour. Using classical molecular dynamics simulations and umbrella sampling techniques, the study finds that dimethylation of the primary amine group and methoxy substitution at position 5 increase permeability, while positional substitutions on the indole groups and protonation decrease permeability.
Category: Papers
Published: 2024-03-05
This review (2024) explores the impact of participant expectations on psychedelic clinical trials. It highlights the challenge of maintaining blinding as doses increase and discusses the potential bias introduced by positive expectancy. The review covers expectancy effects in both micro- and macrodose trials, suggesting that understanding and managing expectancy could enhance trial rigour and treatment outcomes in future psychedelic research.
Category: Papers
Published: 2024-03-05
This interventional study, named PREDICT and conducted by Maastricht University, aims to comprehensively evaluate the acute and subacute effects of 2C-B compared to psilocybin and a placebo.
Category: Trials
Published: 2024-02-29
This double-blind, placebo-controlled trial (n=80) investigates the safety and efficacy of GH001, containing mebufotenin (5-MeO-DMT), in treating treatment-resistant depression (TRD).
Category: Trials
Published: 2024-02-29
This phase I, double-blind, randomized, placebo-controlled crossover trial (n=25) explores the acute and subacute effects of inhaled N,N-Dimethyltryptamine (DMT) in healthy adults.
Category: Trials
Published: 2024-02-29
This quadruple-masked, randomised, multi-centre Phase II study (n=225) investigates the efficacy and safety of a single intranasal dose of BPL-003, combined with psychological support, in patients with treatment-resistant depression (TRD).
Category: Trials
Published: 2024-02-29
This open-label Phase II trial (n=12) is designed to assess the acute and subacute effects of inhaled N,N-Dimethyltryptamine (DMT) in patients with partial response in depression.
Category: Trials
Published: 2024-02-29

Psychedelic Database

Find everything on psychedelics as medicine. This page allows you to search through our whole database, from research papers to news articles, and from clinical trials to academic articles.

Next to our databases, don’t forget to check out our reports. The reports bring together the separate pieces of information from our database entries into written reports.