Database

Emmanuelle Schindler is a board-certified Neurologist at Yale School of Medicine in New Haven, with a PhD in Neuroscience. Her research focus on enhancing the understanding of and improving the lives of patients with cluster headache.

This systematic review (2022) explores the potential mechanisms by which combined psilocybin and mindfulness treatment could adjust anomalous neural activity underlying social anxiety disorder (SAD) and exert therapeutic effects. Proposed mechanisms include changes in cognitive processes like biased attention to threats linked to SAD by modulating connectivity of the salience network and more.

This preprint (2022) assessed 11,821 publicly available natural language testimonials from Erowid using three machine learning models to help quantify changes in conscious awareness optimal for treatment by psychedelics. Together, the models elucidate a neurobiologically-informed, temporally-sensitive portrait of drug-induced subjective experiences. MDMA was singularly linked to mid-experience swelling of "Love", potent psychedelics like DMT, and 5-MeO-DMT were associated with "Mystical Experiences", while other tryptamines were associated with an emotional constellation of "Surprise", "Curiosity" and "Realization."

This is a Phase 2, multi-center, randomized, double-blind, parallel-group, dose-finding study to assess the effect of 4 doses of MM-120 (25, 50, 100 or 200 μg freebase-equivalent) for the treatment of anxiety symptoms in subjects diagnosed with generalized anxiety disorder (GAD).

This multicenter, triple-blind, phase 2, randomized controlled trial will evaluate the efficacy and safety of psilocybin therapy compared to an active control in treating demoralization in adults near the end of life (≤2 years life expectancy).

Psychedelics feature in the BBC yet again. This time, Clare Tweedy dissects how psychedelics can help to treat depression.

The former chief of the Australian defence force, Chris Barrie, is campaigning to remove barriers stymying doctors from using MDMA to treat veterans suffering post-traumatic stress disorder and depression, saying he hopes “common sense is going to prevail”.

Tripp has raised $11.2 million in funding to help it continue to create meditation apps that power the “mindful metaverse.”

Cybin has announced the team of 28 esteemed faculty and advisors who will lead the Company’s EMBARK Psychedelic Facilitator Training Program. Recognizing the crucial importance of supporting psychedelic study facilitators with quality training, Cybin has brought together recognized leaders and senior psychedelic-assisted psychotherapy trainers from leading universities and psychedelic research and training organizations.

This survey study (n=750) draws upon the eudaimonic perspective of well-being to investigate the relationship between the extent of post-psychedelic integration and optimal well-being. Results indicated that perceived benefits to narrative self-functioning is one pathway through which integration of psychedelic experience may promote optimal well-being for both clinical and non-clinical populations. Integration techniques that are more self-referential in nature indirectly relate to optimal well-being via perceived benefits.