This open-label trial (n=24) investigates the difference between those who are and aren't taking antidepressants (SSRIs) who will receive SPL026 (DMT fumarate). As a Phase I study, the main concern is safety and tolerability. With 24 participants, some signal on effectiveness might be detected.
This RCT (n=24) does a direct comparison, the first one in a double-blind trial, of MDMA, psilocybin, and 2C-B (a novel psychedelic with MDMA & psilocybin-like effects). Next to a placebo, the dosages of MDMA (125mg) and psilocybin (25mg) are high, whilst that of 2C-B will be a variety of doses (10, 20, 30mg). All participants will receive all compounds and a placebo (cross-over study design).
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