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This prospective docking study compares the effectiveness of docking large libraries against unrefined AlphaFold2 (AF2) models of σ2 and 5-HT2A receptors with docking against experimental structures. It finds high and similar hit rates and affinities for both AF2 and experimental structures, despite conformational differences in orthosteric residues, and suggests that AF2 models, while differing from experimental structures, are still relevant and effective for structure-based ligand discovery.
Category: Papers
Published: 2024-05-22
This open-label pilot study (n=20) investigated the safety and efficacy of intranasal ketamine for treating a single cluster headache (CH) attack. While the primary endpoint of a 50% reduction in pain intensity within 15 minutes was not met, at 30 minutes post-treatment, pain intensity was significantly reduced by 59% on an 11-point scale, with no serious adverse events reported.
Category: Papers
Published: 2024-05-22
This randomized controlled trial (n=116) investigated the psychological mechanisms of ketamine's antidepressant effects. Participants receiving ketamine reported significantly heightened feelings of awe compared to those receiving a placebo. Awe experiences, as measured by the Awe Experience Scale (AWE-S), mediated depression outcomes (% improvement in MADRS scores) at multiple time points (24 hours and 5, 12, 21, and 30 days) post-infusion, indicating a potential role of awe in ketamine's therapeutic efficacy for depression.
Category: Papers
Published: 2024-05-22
This exploratory study (n=155) investigates the relationship between changes in metaphysical beliefs and death anxiety following a significant psychedelic experience. It finds a significant overall reduction in death anxiety, with improvements correlated positively with increased belief in panpsychism, while no other metaphysical beliefs showed a correlation.
Category: Papers
Published: 2024-05-22
This theory-building paper (2024) examines how psychedelic experiences reduce fear of death by promoting non-physicalist metaphysical beliefs. It supports the "Relaxed Beliefs Under Psychedelics" (REBUS) model over other models of psychedelic therapy and argues that these belief changes undermine the use of psychedelics in naturalizing spirituality within the "neuroexistentialist" framework.
Category: Papers
Published: 2024-05-20
This triple-blinded, randomised, active, placebo-controlled trial (n=34) will investigate the effects of ketamine in combination with standard inpatient addiction therapy for adults suffering from depression and alcohol use disorder (AUD).
Category: Trials
Published: 2024-05-16
This qualitative study (n=26) explored existential distress following psychedelic experiences, finding persistent preoccupation with sense-making and confusion about existence and purpose. Participants reported cognitive, emotional, social, bodily, and functional impacts. They managed distress through embodiment practices and social/cognitive normalization.
Category: Papers
Published: 2024-05-14
This retrospective observational cohort study (n=966 esketamine initiators, n=39,219 controls) examines factors influencing esketamine initiation and continuation for treatment-resistant depression (TRD). Initiators resided closer to treatment centres, with initiation rates decreasing significantly with distance. Factors associated with increased initiation included posttraumatic stress disorder, suicidal ideation, and male sex, while Medicaid, substance use disorder, older age, and greater distance were associated with lower initiation rates.
Category: Papers
Published: 2024-05-14
This pre-print brain imaging study (n=16, MEG) investigates the neural effects of psychedelics, focusing on hierarchy based on directed functional connectivity (FC). Administering LSD to healthy participants, researchers find LSD diminishes the asymmetry of directed connectivity over time and enhances machine learning classifiers' accuracy in distinguishing LSD from placebo based on hierarchy metrics. These findings suggest LSD weakens the brain's directed connectivity hierarchy by balancing neural signal senders and receivers.
Category: Papers
Published: 2024-05-14
This molecular study investigates the underpinnings of 5-MeO-DMT pharmacology and its therapeutic potential through cryogenic electron microscopy structures of 5-HT1A, medicinal chemistry, receptor mutagenesis, and mouse behaviour. The research characterizes molecular determinants of 5-HT1A signalling potency, efficacy, and selectivity, contrasting the structural interactions and pharmacology of 5-MeO-DMT with LSD and clinically used 5-HT1A agonists.
Category: Papers
Published: 2024-05-14

Psychedelic Database

Find everything on psychedelics as medicine. This page allows you to search through our whole database, from research papers to news articles, and from clinical trials to academic articles.

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