N,N-dimethyltryptamine (DMT) is a powerful yet short-lived hallucinogenic drug, which is a natural component of many living plants and animals and is found in high concentrations in some plants used for psychedelic purposes, such as Mimosa tenuiflora and Banisteriopsis caapi (one half of the ayahuasca brew). Similar to psilocybin and LSD, DMT produces a visual and hallucinogenic experience, yet at a much more intense and shorter duration. DMT is also listed as a Schedule I controlled substance under the UN Convention on Controlled Substances 1971. The chemical structure of DMT is similar to the anti-migraine drug sumatriptan, and it acts as a non-selective partial agonist at most or all of the serotonin receptors, particularly at the serotonin 2a receptor. There exists anecdotal evidence that DMT can be used to treat conditions such as chronic migraines. While research is now beginning to probe into the mechanisms of DMT, notably at Imperial College London, there is virtually no modern clinical data on the use of pure DMT for any medical purposes. A low dosage of DMT is considered to be between 0.05 and 0.1 milligram/kilograms body weight. The ‘psychedelic’ threshold for DMT is believed to be 0.2 milligram/kilograms body weight.
These are the institutes, from companies to universities, who are working on DMT research.
Enveric Biosciences is a publicly-traded biotechnology company predominantly focused on leveraging cannabinoids as treatments for cancer and oncology treatment-caused indications. They have recently expanded into the psychedelic space through the acquisition of MagicMed in September 2021.
Small Pharma works on the development of two drugs. Together with Imperial College London they are developing intravenous administration DMT. The other project is a variant on ketamine (SPL801B).
These are some of the best-known people, from researchers to entrepreneurs, working with DMT.
Linked Research Papers & Trials
Pro & Business members will be able to see all linked papers and trials directly on this compound page.
See the information directly on this page with a paid membership.