million people affected worldwide
Current Treatments
Psychedelic research currently is in Phase Ia
Psychedelics are being investigated for several headache disorders. These include migraines and cluster headaches which are two separate, but both debilitating, headache disorders with different expressions and underlying processes.
This topic page is linked to our papers but doesn’t yet have a full explanation.
Headache disorders are part of our Pain topic.
Highlighted Institutes
These are the institutes, from companies to universities, who are working on Headache Disorders.
Highlighted People
These are some of the best-known people, from researchers to entrepreneurs, working on Headache Disorders.
Linked Research Papers about Headache Disorders
The use of illicit drugs as self-medication in the treatment of cluster headache: results from an Italian online survey
Efficacy of ketamine in the treatment of migraines and other unspecified primary headache disorders compared to placebo and other interventions: a systematic review
Response of cluster headache to psilocybin and LSD
Self-Reported Efficacy of Treatments in Cluster Headache: a Systematic Review of Survey Studies
Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity
Psychoactive substances as a last resort—a qualitative study of self-treatment of migraine and cluster headaches
Unauthorized Research on Cluster Headache
Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin
Exploratory investigation of a patient-informed low-dose psilocybin pulse regimen in the suppression of cluster headache: Results from a randomized, double-blind, placebo-controlled trial
Psilocybin dose-dependently causes delayed, transient headaches in healthy volunteers
Collective self-experimentation in patient-led research: How online health communities foster innovation
The non-hallucinogen 2-bromo-lysergic acid diethylamide as preventative treatment for cluster headache: An open, non-randomized case series
Indoleamine Hallucinogens in Cluster Headache: Results of the Clusterbusters Medication Use Survey
Increased use of illicit drugs in a Dutch cluster headache population