Headache Disorders

million people affected worldwide

Current Treatments

Psychedelic research currently is in Phase Ia

Psychedelics are being investigated for several headache disorders. These include migraines and cluster headaches which are two separate, but both debilitating, headache disorders with different expressions and underlying processes.

This topic page is linked to our papers but doesn’t yet have a full explanation.

Headache disorders are part of our Pain topic.

Highlighted Institutes

These are the institutes, from companies to universities, who are working on Headache Disorders.

Highlighted People

These are some of the best-known people, from researchers to entrepreneurs, working on Headache Disorders.

Linked Research Papers about Headache Disorders

The use of illicit drugs as self-medication in the treatment of cluster headache: results from an Italian online survey

Efficacy of ketamine in the treatment of migraines and other unspecified primary headache disorders compared to placebo and other interventions: a systematic review

Response of cluster headache to psilocybin and LSD

Self-Reported Efficacy of Treatments in Cluster Headache: a Systematic Review of Survey Studies

Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity

Psychoactive substances as a last resort—a qualitative study of self-treatment of migraine and cluster headaches

Unauthorized Research on Cluster Headache

Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin

Exploratory investigation of a patient-informed low-dose psilocybin pulse regimen in the suppression of cluster headache: Results from a randomized, double-blind, placebo-controlled trial

Psilocybin dose-dependently causes delayed, transient headaches in healthy volunteers

Collective self-experimentation in patient-led research: How online health communities foster innovation

The non-hallucinogen 2-bromo-lysergic acid diethylamide as preventative treatment for cluster headache: An open, non-randomized case series

Indoleamine Hallucinogens in Cluster Headache: Results of the Clusterbusters Medication Use Survey

Increased use of illicit drugs in a Dutch cluster headache population