Ketamine Use in Electroconvulsive Therapy

The purpose of this study is to determine whether combination of ketamine plus electroconvulsive therapy improves depressive symptoms decreasing cognitive side effects.

Topic Depression
Compound Placebo Ketamine
Status Withdrawn
Results Published
Start date 01 January 2014
End date 01 January 2016
Chance of happening 0%
Phase Not Applicable
Design Blinded
Type Interventional
Generation First
Participants 0
Sex All
Age 18- 99
Therapy No

Trial Details

This study will compare the clinical response to brief pulse ECT with infusion of ketamine 0.5 mg/kg versus brief pulse electroconvulsive therapy with infusion of placebo (saline) in major depression. We also will compare levels of cognitive impairment among these groups, compare levels of quality of life among these groups, compare levels of BDNF among these groups. We also will study if levels of 25-hydroxyvitamin D are associated with cognitive impairment in subjects undergoing ECT.

NCT Number NCT02012335

Sponsors & Collaborators

Hospital de Clinicas de Porto Alegre
This company doesn't have a full profile yet, it is linked to a clinical trial.

Measures Used

Hamilton Depression Rating Scale
The Hamilton Depression Rating Scale (HDRS) is a multiple item questionnaire used to provide an indication of depression, and as a guide to evaluating recovery. The scale consists of 17 items which each item being scoring on a 3 or 5 point scale. The higher the score, the more likely a person is depressed.

Data attribution

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