Clinical Trial of the Use of Ketamine in Treatment Resistant Depression

The purpose of this study is to determine the efficacy of the use of intravenous low-dose ketamine in the treatment of treatment-resistant depression (TRD), as well as the changes in Glutamate neurotransmission and inflammatory serum markers.

Topic Treatment-Resistant Depression
Compound Ketamine
Country Mexico
Visit trial
Status Unknown status
Results Published
Start date 01 May 2014
Chance of happening 0%
Phase Phase IV
Design Open
Type Interventional
Generation First
Participants 20
Sex All
Age 18- 65
Therapy No

Trial Details

The purpose of this study is to determine the efficacy of the use of intravenous low-dose ketamine (0.5 mg/kg) in the treatment of treatment-resistant depression (TRD), as well as the changes in Glutamate neurotransmission measured by Magnetic Resonance Imaging Spectroscopy and inflammatory serum markers (IL-6, TNF-alpha).

NCT Number NCT02610712

Sponsors & Collaborators

National Institute of Neurology and Neurosurgery Mexico
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Measures Used

Hamilton Depression Rating Scale
The Hamilton Depression Rating Scale (HDRS) is a multiple item questionnaire used to provide an indication of depression, and as a guide to evaluating recovery. The scale consists of 17 items which each item being scoring on a 3 or 5 point scale. The higher the score, the more likely a person is depressed.

Data attribution

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