Brain Activity Effects of Psychedelic Medicines in Healthy Volunteers

This interventional trial (n=0, withdrawn) aimed to investigate the brain activity effects of psychedelic medicines, specifically psilocybin or MDMA, in healthy volunteers.

The trial was initiated to understand changes in neural activity associated with a single session of psychedelic drug exposure, utilising electroencephalography (EEG) measurements taken before and after exposure. Participants were to undergo a single drug exposure session, either individually or in small groups, with support from two therapists.

The primary outcomes included EEG measures such as N100 and N170 obtained during various tasks, alongside secondary outcomes covering personality, side effects, trust, mindfulness, and metaphysical beliefs.

The trial’s design involved non-randomised allocation, and while it was planned to recruit participants until August 2025, the recruitment was later withdrawn due to a lack of funding, staff, or facilities.

The study was funded by Transcranial Magnetic Stimulation Clinics Australia and Mind Medicine Australia and was conducted under the leadership of Dr Neil Bailey. The data sharing statement indicated that both EEG data and self-report data would be made available to the public, with individual participant data being shared three months after the main results publication, with no specified end date.

Topic Healthy Subjects
Compound MDMA Psilocybin
Country Australia
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Trial Details



Trial Number

Sponsors & Collaborators

Mind Medicine Australia
Mind Medicine Australia is a non-profit that provides a conference, training for psychedelic-assisted therapies, supports research, and does advocacy for psychedelics in Australia (and Asia-Pacific).

Data attribution

A large set of the trials in our database are sourced from ClinicalTrials.gov (CTG). We have modified these post to display the information in a more clear format or to correct spelling mistakes. Our database in actively updated and may show a different status (e.g. completed) if we have knowledge of this update (e.g. a published paper on the study) which isn't reflected yet on CTG. If a trial is not sourced from CTG, this is indicated on this page and you can follow the link to the alternative source of information.