Abuse Potential and Human Pharmacology of Methylone

This trial (n=17) aimed to assess the abuse potential, subjective and physiological effects, pharmacokinetic parameters, and metabolism of methylone (200mg), a synthetic cathinone popularized as an alternative to illegal psychostimulants such as MDMA (100mg) and mephedrone.

A pilot study was conducted to determine the appropriate methylone dose for the trial. The study involved the controlled administration of a single oral dose of methylone. Data on the human pharmacology of methylone is currently limited to user experiences reported in internet forums or intoxication reports.

Topic Healthy Subjects
Compound MDMA
Country Spain
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Trial Details



Trial Number

Sponsors & Collaborators

Germans Trias i Pujol University Hospital
The Institute for Health Science Research Germans Trias i Pujol (IGTP) is a leading biomedical research centre in Badalona, Barcalona, Spain.

Papers

Pharmacological effects of methylone and MDMA in humans
This double-blind study (n=17) compared the pharmacological effects of methylone (200mg) and MDMA (100mg), for which methylone is a popular substitute. The results showed that methylone could significantly increase blood pressure and heart rate and induce pleasurable effects similar to MDMA, including stimulation, euphoria, well-being, enhanced empathy, and altered perception.

Data attribution

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