This study was a Phase I, double-blind, placebo-controlled, randomised study of very low dose LSD.
Healthy volunteers aged 55 to 75 years with no use of LSD in the past 5 years were screened within 28 days of randomization.
Subjects who met all inclusion and no exclusion criteria and provided written informed consent were randomised a 1:1:1:1 ratio to receive 6 doses of 5 µg, 10 µg, or 20 µg LSD or placebo, at 4-day intervals for 21 days (on Study Days 1, 5, 9, 13, 17, and 21).
A follow-up visit was conducted approximately 4 weeks after the last dose of LSD. A total of 48 subjects were enrolled.
Topic Healthy Subjects
Country United States of America
Visit trial
Status
Completed
Results Published
Yes
Start date
29 June 2015
End date
05 November 2015
Chance of happening
100%
Phase
Phase I
Design
Blinded
Type
Interventional
Generation
First
Participants
48
Sex
All
Age
55- 57
Therapy
No
Trial Details
The magnitude of the effect of LSD was explored across specific PD measures. These included: Cognition and affect, including evaluation of memory, temporal perception, executive function, and learning Subjective effects Proprioception and balanceNCT Number NCT04421105
Sponsors & Collaborators
EleusisEleusis is a clinical-stage life sciences company that studies and develops psychedelic drugs for therapeutic use. Since 2013 the company has been researching psychedelics and is now developing ELE-Psilo (psilocybin) for depression that is in Phase I.
Papers
The effects of microdose LSD on time perception: a randomised, double-blind, placebo-controlled trialThis was the first double-blind and placebo-controlled study (n=48) into the effects of microdosing LSD. The topic was quite specific (time perception), but they also reported on other cognitive changes (of which there were few and at a very small scale).
Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers
This Phase I, double-blind, placebo-controlled, randomized study (n=48) indicates that LSD administration (tested up to 20µg) didn't produce any negative effects for healthy older participants (mean age=63).
Measures Used
5-Dimensional Altered States of Consciousness QuestionnaireThe 5D-ASC scale measures altered states of consciousness and contains 94 items (visual analog scales).