5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder

This double-blind clinical trial (n=66) will study the effects of psilocybin in the treatment of tobacco (cigarette) addiction. The study is conducted as a collaboration between Johns Hopkins, the University of Alabama at Birmingham, and New York University.

This is a multi-site, double-blind, randomized clinical trial of the 5-HT2A receptor agonist psilocybin for smoking cessation. Three sites with experience in conducting psilocybin research will be involved in this trial: Johns Hopkins University (JHU), the University of Alabama at Birmingham (UAB), and New York University (NYU). The proposed study will treat 66 participants (22 at each site), randomized to receive either: 1) oral psilocybin (30 mg in session 1 and either 30 mg or 40 mg in session 2); or 2) oral niacin (150 mg in session 1 and either 150 mg or 200 mg in session 2), with sessions 1 week apart.

Topic Smoking Addiction
Compound Psilocybin
Country United States of America
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Trial Details



Trial Number

Sponsors & Collaborators

Johns Hopkins University
Johns Hopkins University (Medicine) is host to the Center for Psychedelic and Consciousness Research, which is one of the leading research institutes into psychedelics. The center is led by Roland Griffiths and Matthew Johnson.

New York University
The Center for Psychedelic Medicine performs health-focused research across the translational spectrum, from basic science to large-scale clinical trials.

University of Alabama
Researchers at the University of Alabama are investigating the potential use of psychedelics in a number of disorders.

National Institute on Drug Abuse
This company doesn't have a full profile yet, it is linked to a clinical trial.

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