The role of 5-HT2 and 5-HT1A receptors in 3,4-methylenedioxymethamphetamine (MDMA) induced memory impairment and impulsivity.

This interventional crossover trial (n=18) aimed to investigate the role of 5-HT2 and 5-HT1A receptors in MDMA-induced memory impairment and impulsivity.

Subjects, aged between 18 and 40 years with MDMA experience, were treated with different combinations of drugs including ketanserin, pindolol, and MDMA, alongside placebos. The study, conducted at Maastricht University, Netherlands, was designed to assess neurocognitive measures of memory and impulse control at Tmax.

It was hypothesized that an acute dose of MDMA would impair learning and memory, which could be reversed by coadministration of ketanserin or pindolol, depending on the receptors involved.

Participants had to meet specific inclusion criteria, including previous MDMA use and good physical health, while exclusion criteria encompassed factors such as drug abuse history and cardiovascular abnormalities. The trial, approved by the ethics review, began in March 2010 and enrolled 18 participants. Contacts for the study were provided for both public and scientific inquiries.

Topic Healthy Subjects
Compound Placebo MDMA
Country Netherlands
Visit trial
Status Completed
Results Published No
Start date 01 March 2010
End date 01 January 2011
Design Open
Type Interventional
Generation First
Participants 18
Sex All
Age 18- 40
Therapy No

Trial Details

This crossover trial (n=18) investigated MDMA's impact on memory and impulsivity, exploring receptor roles. Subjects received drug combinations including ketanserin, pindolol, and MDMA alongside placebos. Conducted at Maastricht University, Netherlands, it aimed to assess neurocognitive measures at Tmax. Approved by ethics review, the study commenced in March 2010, enrolling 18 participants.

NCT Number NL2227

Sponsors & Collaborators

Maastricht University
Maastricht University is host to the psychopharmacology department (Psychopharmacology in Maastricht) where various researchers are investigating the effects of psychedelics.

Papers

Effects of acute MDMA intoxication on mood and impulsivity: role of the 5-HT 2 and 5-HT 1 receptors
This double-blind, placebo-controlled, within-subject study (n=17) explored the role of 5-HT1 and 5-HT2 receptors in MDMA effects on mood and impulsivity. It found that 5-HT2 receptors mediate positive moods induced by MDMA but not negative moods or impulsivity. There were no mediating effects of 5-HT1 receptors.

Data attribution

A large set of the trials in our database are sourced from ClinicalTrials.gov (CTG). We have modified these post to display the information in a more clear format or to correct spelling mistakes. Our database in actively updated and may show a different status (e.g. completed) if we have knowledge of this update (e.g. a published paper on the study) which isn't reflected yet on CTG. If a trial is not sourced from CTG, this is indicated on this page and you can follow the link to the alternative source of information.