THC and Ketamine Effects in Humans: Relation to Neural Oscillations and Psychosis

The aim of the research protocol is to evaluate cannabinoid-glutamate interactions in humans. As part of this aim the investigators will assess the safety and tolerability of the combination of NMDA antagonist, ketamine, and the cannabinoid, delta-9-tetrahydrocannabinol (THC), in healthy adult subjects, and characterize the interactive effects of ketamine and THC on various electrophysiological (EEG), cognitive, and behavioral outcomes.

Topic Healthy Subjects
Compound Placebo Ketamine
Country United States of America
Visit trial
Status Recruiting
Results Published
Start date 24 September 2019
End date 01 December 2021
Chance of happening 100%
Phase Phase I
Design Blinded
Type Interventional
Generation First
Participants 21
Sex All
Age 18- 45
Therapy No

Trial Details

The investigators will examine the contributions of the cannabinoid receptor (CB1R) and N-methyl D-aspartate receptor (NMDAR) systems to psychosis in healthy humans beings using THC and ketamine respectively (both alone and in combination). Healthy subjects (n=21) will receive THC (active or placebo) followed by ketamine (active or placebo) in a double blind, randomized, crossover (2x2) design. Psychotomimetic effects will be assessed before and at various time points after the drug infusions. EEG indices of information processing, specifically neural oscillations, will be assessed during peak drug effects.

NCT Number NCT04199468

Sponsors & Collaborators

Yale University
The Yale Psychedelic Science Group was established in 2016.

Data attribution

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