Sustained Ketamine Effectiveness for Suicidal Ideation (SKESI)

This observational cohort study (n=128) will evaluate the sustained effectiveness of intravenous (IV) ketamine for suicidal ideation in adults experiencing a suicidal crisis due to major depressive disorder.

Conducted at the University Hospital, Montpellier, this retrospective study analyses medical records of patients treated with IV ketamine in the Psychiatric Emergency and Post-Emergency Department between June 2022 and March 2024.

The study aims to assess changes in suicidal ideation and behaviour at multiple time points—7 days, 1 month, and 3 months post-treatment—using the Columbia-Suicide Severity Rating Scale (C-SSRS). Secondary outcomes include evaluating depressive symptoms through the Montgomery-Åsberg Depression Rating Scale (MADRS) and tracking hospitalisations or emergency visits related to suicidal ideation.

Topic Suicidality Depression
Compound Ketamine
Country France
Visit trial
Status Completed
Results Published No
Start date 01 December 2023
End date 23 September 2024
Phase Not Applicable
Design Open
Type Observational
Generation First
Participants 128
Sex All
Age 18- 99
Therapy Yes

Trial Details

As part of the usual clinical activity of the Emergency and Post-Emergency Psychiatric Department, IV ketamine is used to treat suicidal crises in depressed patients hospitalized as an add-on to the treatment of depression. This infusion can be repeated. We systematically reassess patients twice in the month following the last infusion, to ensure that the suicidal crisis is progressing. Psychometric assessments are part of routine care, to ensure systematic evaluation of psychopathology, intensity of depression and suicidality. We therefore re-used existing data from the medical records of patients who had received ketamine infusions to assess the effect of ketamine on suicidal ideation and behaviour.

Trial Number NCT06806475

Data attribution

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