Mechanistic Studies of Psilocybin in Headache Disorders

This interventional trial (n=50) will explore the mechanisms of psilocybin in headache disorders, focusing on migraine sufferers and healthy controls.

Conducted by Yale University, the study aims to understand the effects of psilocybin on brain function and inflammation. Participants will be administered either 10 mg of psilocybin or a placebo, with brain imaging (fMRI and PET), actigraphy, and sleep EEG assessments before and after the drug administration. The study will also monitor changes in peripheral inflammation markers and circadian rhythms.

The primary goal is to investigate how psilocybin influences brain connectivity and inflammation in migraine patients compared to healthy controls. This research is expected to provide insights into the therapeutic potential of psilocybin for headache disorders.

Topic Headache Disorders
Compound Psilocybin
Country United States of America
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Trial Details



Trial Number

Sponsors & Collaborators

Yale University
The Yale Psychedelic Science Group was established in 2016.

Data attribution

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