MDMA and prosocial behavior: The role of the 2a-serotonin receptor

This interventional trial (n=20) investigates the neurobiological mechanisms underlying MDMA-induced prosocial behaviour, specifically focusing on the role of the 5-HT2a receptor.

Led by Maastricht University’s Dr. Kim Kuypers and supported by NWO, the study aims to understand how MDMA affects social cognition and interaction, and whether these effects are influenced by social context.

Participants aged 18-35 with MDMA experience undergo a four-way crossover study, receiving single doses and combinations of MDMA and the 5-HT2a blocker ketanserin. The study measures cognitive and affective empathy using various tasks.

Recruitment is ongoing, with an anticipated start date of January 2013.

Original (Dutch) title: MDMA en prosociaal gedrag: De rol van de 2a-serotonine receptor.

Topic Healthy Subjects
Compound MDMA Placebo
Country Netherlands
Visit trial
Status Recruiting
Results Published No
Start date 30 January 2013
End date 01 January 2015
Phase Not Applicable
Design Blinded
Type Interventional
Generation First
Participants 20
Sex All
Age 18- 35
Therapy No

Trial Details

This trial (n=20) led by Dr. K.P.C. Kuypers at Maastricht University investigates how MDMA impacts prosocial behaviour and the role of the 5-HT2a receptor. Participants, aged 18-35 with MDMA experience, undergo a study receiving MDMA and/or ketanserin. The study measures empathy through tasks. Recruitment is ongoing, anticipated to start in January 2013.

NCT Number NL42465.068.12

Sponsors & Collaborators

Maastricht University
Maastricht University is host to the psychopharmacology department (Psychopharmacology in Maastricht) where various researchers are investigating the effects of psychedelics.

Data attribution

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