Ketamine for Depression: An MRI Study

Ketamine has been shown to decrease symptoms of anxious depression quickly. This decrease has been shown to last for up to one month. MRI technology will be used before and after ketamine for patients with depression to examine the extent to which certain brain areas predict ketamine’s antidepressant effects.

Topic Depression
Compound Ketamine
Country United States of America
Visit trial
Status Completed
Results Published No
Start date 01 March 2016
End date 29 December 2017
Phase Phase IV
Design Open
Type Interventional
Generation First
Participants 25
Sex All
Age 18- 64
Therapy No

Trial Details

Ketamine's antidepressant effects were measured with Hamilton Depression Rating Scale (HDRS). MRI data will also be analyzed to examine the extent to which certain brain areas predict ketamine's antidepressant effects.

Trial Number NCT02544607

Sponsors & Collaborators

Massachusetts General Hospital
Massachusettes General Hospital has launched the MGH Center for the Neuroscience of Psychedelics. The announcement has now been done via YouTube, and the formal launch will be in fall 2020.

Brain and Behavior Research Foundation
This company doesn't have a full profile yet, it is linked to a clinical trial.

National Institutes of Health
This company doesn't have a full profile yet, it is linked to a clinical trial.

Measures Used

Hamilton Depression Rating Scale
The Hamilton Depression Rating Scale (HDRS) is a multiple item questionnaire used to provide an indication of depression, and as a guide to evaluating recovery. The scale consists of 17 items which each item being scoring on a 3 or 5 point scale. The higher the score, the more likely a person is depressed.

Data attribution

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