Ketamine-assisted psychotherapy for methamphetamine use disorder

This open-label safety and feasibility pilot trial (n=20) will study ketamine-assisted psychotherapy for methamphetamine use disorder in adults.

The study, titled KAPPA, aims to determine if combining ketamine with cognitive behavioural therapy (CBT) is a safe and feasible treatment approach for methamphetamine use disorder.

Conducted by St Vincent’s Hospital Sydney and funded by the Australian Government Department of Health and Aged Care, the trial involves four weekly CBT sessions, with ketamine administered subcutaneously before the second, third, and fourth sessions. Participants’ safety will be monitored through adverse event reporting and various health assessments.

Feasibility will be evaluated based on recruitment time, session attendance, and participant retention. The trial will commence in September 2024.

A study protocol can be found here.

Topic Addiction Opioid Use Disorder Alcohol Use Disorder
Compound Ketamine
Country Australia
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Trial Details



Trial Number

Sponsors & Collaborators

St Vincent's Hospital Melbourne


Data attribution

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