Interactions between 3,4-methylenedioxymethamphetamine (MDMA or ’ecstasy’) and Ä9-tetrahydrocannabinol (THC or ‘marihuana’) in humans

This completed interventional trial (n=16) investigated the interactions between MDMA and THC in humans.

Conducted at UMC St. Radboud Nijmegen, the study aimed to determine how the acute effects of MDMA on cognitive function, prolactin and cortisol levels, body temperature, heart rate, and blood pressure are influenced by co-exposure to THC.

Participants, regular users of ecstasy and cannabis, received 100 mg MDMA orally and 4, 6, and 6 mg THC vaporised alone and combined. Outcome measures included cardiovascular effects, psychomotor performance, memory and learning, sedation, subjective effects, core body temperature, sympathetic responsiveness, serotonergic responsiveness, and side effects.

Recruitment began on 01-06-2006 and enrolled 16 participants, meeting eligibility criteria such as age between 18-40 years, regular use of ecstasy and THC, good physical and mental health, and written informed consent. The study employed a crossover design with double-blinded masking and placebo arm. Ethical approval was obtained on 16-05-2008.

The results from this trial were published here and here.

Topic Healthy Subjects
Compound MDMA Placebo
Country Netherlands
Visit trial
Status Completed
Results Published No
Start date 01 June 2006
End date 01 January 2009
Design Blinded
Type Interventional
Generation First
Participants 16
Sex All
Age 18- 40
Therapy No

Trial Details

This completed trial (n=16) explored how MDMA interacts with THC in humans. It examined the acute effects of MDMA on various factors like cognitive function and heart rate, considering co-exposure to THC. Conducted at UMC St. Radboud Nijmegen, it involved regular users of ecstasy and cannabis who received MDMA and THC alone and combined. Outcome measures included cardiovascular effects, psychomotor performance, memory, sedation, and more. The study, starting in June 2006, used a crossover design with double-blinded masking and placebo arm, receiving ethical approval on 16-05-2008.

NCT Number NL1271

Sponsors & Collaborators

Radboud University
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Data attribution

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