Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humans

The goal of this fixed order, open-label, dose-escalation study is to investigate the safety and efficacy of specific doses of dimethyltryptamine (DMT) in humans.

Topic Depression
Compound DMT
Country United States of America
Visit trial
Status Active, not recruiting
Results Published
Start date 17 March 2021
End date 01 June 2022
Chance of happening 100%
Phase Phase I
Design Open
Type Interventional
Generation First
Participants 6
Sex All
Age 21- 65
Therapy No

Trial Details

The results of this study will inform the doses to be used in a larger, double-blind, randomized, placebo-controlled, crossover study. Since the goal of the open-label study is to inform the double-blind, randomized, placebo-controlled study, the investigators are citing the hypothesis of the latter solely for providing context.

The investigators hypothesize that the administration of DMT will result in neuroplastic changes in healthy and depressed subjects. These changes in neuroplasticity will be indexed using electroencephalographic (EEG) measures and tasks. These neuronal changes may in parallel cause changes in mood measured both in healthy and depressed subjects, which will be captured using appropriate psychometric measures of mood.

NCT Number NCT04711915

Sponsors & Collaborators

Yale University
The Yale Psychedelic Science Group was established in 2016.

Heffter Research Institute
The Heffter Research Institute has been advancing psychedelics (psilocybin) as medicines since 1993.

Data attribution

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