Effects of Psilocybin on Shared Experience

This interventional trial (n=30) will examine the effects of psilocybin on brain synchrony and cognitive function in healthy volunteers.

Conducted by Western University, Canada, the study aims to assess whether psilocybin can influence brain synchrony during film processing and other tasks.

Participants will take psilocybin or a placebo in two separate brain scanning sessions. During these sessions, they will watch film clips, perform cognitive tasks, and undergo various neuroimaging scans to evaluate changes in brain activity and synchrony. The study will also explore how psilocybin affects cognition through memory and reasoning tests.

The primary outcome measure will be intersubject correlation (ISC), assessing brain synchrony between participants. Secondary outcomes include cognitive performance in memory, verbal reasoning, and logical reasoning tasks.

The study begins in September 2024 and is expected to complete by September 2025.

Topic Healthy Subjects Neuroscience
Compound Psilocybin
Country Canada
Visit trial
Status Not yet recruiting
Results Published No
Start date 01 September 2024
End date 30 September 2025
Phase Not Applicable
Design Open
Type Interventional
Generation First
Participants 30
Sex All
Age 19- 99
Therapy No

Trial Details

This clinical trial aims to evaluate whether psilocybin affects brain synchrony, a method used to detect awareness in vegetative or minimally conscious patients, by examining how brain activity synchronises when individuals watch films. By conducting the trial with healthy volunteers, the study seeks to determine if psilocybin enhances or diminishes brain synchrony and if these changes reflect individual conscious experiences. Participants will undergo brain scans while watching films, performing mental tasks, and listening to music, both under the influence of psilocybin and a placebo. Additionally, they will engage in cognitive and visual tasks to assess memory, reasoning, and planning abilities.

NCT Number NCT06529939

Data attribution

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