Effects of Ketamine on Mentalizing and Metacognition in Healthy Volunteers

This randomised controlled trial (n=70) investigated the effects of ketamine on mentalizing and metacognition in healthy volunteers.

Conducted by University Hospital, Bonn, the study aimed to understand if ketamine could induce difficulties in social cognition similar to those observed in people with schizophrenia. Participants were administered ketamine or a placebo intravenously while completing a mentalizing task in an fMRI scanner.

Primary outcome measures included changes in mentalizing/theory of mind and neural response to ketamine/placebo during social cognition. Secondary outcome measures included psychotic symptom load and metacognitive typology. The study enrolled 70 participants and was conducted from June 2019 to September 2020.

Topic Healthy Subjects
Compound Ketamine Placebo
Country Germany
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