Effect of Ketamine in Depressive Symptoms of Elderly Patients With Visual Impairment

The prevalence of depression in the elderly is from 4 to 30% and is associated with a lower quality of life, major medical comorbidity, and increased mortality.

Although there are various treatments for depression in the elderly, the study of interventions in resistant depression is limited and there are few reports of the efficacy and safety profile of alternative interventions such as ketamine in the elderly.

The final objective of the present study is to report the effects of a single infusion of ketamine on the depressive symptoms in patients undergoing ophthalmologic surgery

Compound Placebo Ketamine
Country Mexico
Visit trial
Status Completed
Results Published
Start date 15 April 2018
End date 30 July 2018
Chance of happening 100%
Design Blinded
Type Interventional
Generation First
Participants 90
Sex All
Age 60- 99
Therapy No

Trial Details

The prevalence of depression in the elderly is from 4 to 30% and is associated with a lower quality of life, major medical comorbidity, and increased mortality. Although there are various treatments for depression in the elderly, the study of interventions in resistant depression is limited and there are few reports of the efficacy and safety profile of alternative interventions such as ketamine in the elderly. The final objective of the present study is to report the effects of a single infusion of 0.5 mg/kg ketamine in infusion on depressive symptoms assessed using the scale Yesavage's abbreviated Geriatric Depression Scale. This is a randomized double-blind follow-up study in patients over 60 years of age with ocular pathology who required ophthalmological surgery with retrobulbar block and conscious sedation with ketamine. The sample consisted of two groups: a control group and an experimental group with ketamine. The dose used for the study was 0.5mg / kg in slow infusion for two hours. In both groups the Yesavage's questionnaire was applied at three different times; Basally, at the end of the recovery and at 24 hours after the surgery.

NCT Number NCT03473431

Sponsors & Collaborators

Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
This company doesn't have a full profile yet, it is linked to a clinical trial.

Instituto Mexicano del Seguro Social
Instituto Mexicano del Seguro Social is a governmental organization that assists with matters relating to public health and more in Mexico.

Data attribution

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