Drug Effects on Interpersonal Interaction

This double-blind, placebo-controlled crossover trial (n=30) investigated the effects of MDMA (100mg) compared to placebo on feelings of closeness and mood in semi-structured dyadic conversations.

Topic Healthy Subjects
Compound MDMA
Country United States of America
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Trial Details



Trial Number

Sponsors & Collaborators

University of Chicago
Research with psychedelics is taking place at the Human Behavioral Pharmacology Lab at the University of Chicago.

Papers

Drug-induced social connection: both MDMA and methamphetamine increase feelings of connectedness during controlled dyadic conversations
This randomized, controlled trial (n=18 MDMA, n=19 methamphetamine) investigates the effects of MDMA (100 mg) and methamphetamine (MA; 20 mg) on feelings of connectedness during a semi-structured casual conversation with an unfamiliar partner. The study finds that MDMA and MA increased feelings of connection and elevated oxytocin levels compared to placebo. However, a correlation between increased oxytocin levels and feelings of closeness was observed only in the MDMA group, highlighting MDMA's unique empathogenic effects.

Data attribution

A large set of the trials in our database are sourced from ClinicalTrials.gov (CTG). We have modified these post to display the information in a more clear format or to correct spelling mistakes. Our database in actively updated and may show a different status (e.g. completed) if we have knowledge of this update (e.g. a published paper on the study) which isn't reflected yet on CTG. If a trial is not sourced from CTG, this is indicated on this page and you can follow the link to the alternative source of information.