Dose-finding Study for the Combination of DMT and Harmine in Healthy Subjects (DHTP)

This clinical trial (n=16) aims to compare the pharmacokinetic and pharmacodynamic profiles of DMT and Harmine and their safety and tolerability through six study days with varying doses. Participants will be closely monitored for adverse events and receive continuous psychological support in a controlled environment.

Topic Healthy Subjects
Compound DMT Ayahuasca
Country Switzerland
Visit trial
Status Not yet recruiting
Results Published No
Start date 01 May 2023
End date 01 August 2023
Chance of happening 100%
Phase Phase I
Design Blinded
Type Interventional
Generation First
Participants 16
Sex All
Age 25- 45
Therapy No

Trial Details

Participants will undergo a series of six study days with varying doses of DMT and Harmine. The intervention is embedded in controlled environment and continuous psychological support. Pharmacokinetic and pharmacodynamic assessments are obtained over the course of 24 hours on each study visit to estimate dose-exposure relationship and drug-drug-interaction. Additionally, the occurrence of adverse events will be closely monitored throughout the whole study.

NCT Number NCT05829603

Data attribution

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