Come closer: a neurobiological analysis of the prosocial effects of MDMA

This double-blind, placebo-controlled crossover trial (n=24) conducted by Maastricht University explores the prosocial effects of MDMA, oxytocin, and their interaction.

The study aims to understand the neurobiological mechanisms underlying prosocial behaviour induced by MDMA.

Participants, aged 18 to 40 and with MDMA use experience, will receive MDMA, oxytocin, 5-HT1A receptor blocker, or placebos in a crossover design.

The primary outcome measures include empathy and social interaction tasks, with secondary measures assessing oxytocin concentrations and control tasks. Recruitment for this study was completed before February 2024.

The results of the trial can be found here.

Topic Healthy Subjects
Compound MDMA Placebo
Country Netherlands
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Trial Details



Trial Number

Sponsors & Collaborators

Maastricht University
Maastricht University is host to the psychopharmacology department (Psychopharmacology in Maastricht) where various researchers are investigating the effects of psychedelics.

Data attribution

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