Can memantine prevent memory impairment induced by MDMA in humans.

This double-blind, placebo-controlled crossover trial (n=16) investigates whether pretreatment with memantine can prevent the memory impairment typically caused by MDMA in recreational users.

Led by Maastricht University, the study aims to assess memory performance using verbal and prospective memory tests, with event-related potentials measured during the verbal memory task.

Memantine, a drug used in Alzheimer’s treatment, will be administered two hours before MDMA or placebo. The study, employing a 4-way crossover design, anticipates enrolment to begin in April 2011 and seems to have been completed (but the study record not updated).

You can find the results of the study here.

Topic Safety Healthy Subjects
Compound MDMA
Country Netherlands
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Trial Details



Trial Number

Sponsors & Collaborators

Maastricht University
Maastricht University is host to the psychopharmacology department (Psychopharmacology in Maastricht) where various researchers are investigating the effects of psychedelics.

Data attribution

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