Abuse Liability and Human Pharmacology of Mephedrone

The purposes of this study are 1) to evaluate the abuse liability and human pharmacology of mephedrone after oral administration and 2) to compare the pharmacological effects of mephedrone with those obtained after administration of oral MDMA.

Topic Healthy Subjects
Compound Placebo MDMA
Visit trial
Status Completed
Results Published
Start date 01 September 2014
End date 01 December 2014
Chance of happening 100%
Phase Phase I
Design Blinded
Type Interventional
Generation First
Participants 12
Sex Male
Age 18- 44
Therapy No

Trial Details

Mephedrone is a new psychoactive substance (NPS). At present, there are no randomized controlled trials evaluating the effects of mephedrone in humans. The current body of knowledge regarding the acute effects of mephedrone is based on anecdotal, self-reported effects (e.g. internet forums), case reports, and emergency room series and fatalities. The aims of this study are 1) to evaluate the abuse liability and human pharmacology of mephedrone after oral administration and 2) to compare the pharmacological effects of mephedrone with those obtained after administration of oral 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).

NCT Number NCT02232789

Data attribution

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