This study aims to investigate the prophylactic effects of psilocybin in chronic cluster headaches. Subjects will receive a low dose of psilocybin during three sessions spaced over one week. Subjects will maintain a headache diary prior to, during, and after the administrations to document headache frequency, intensity and duration. Subjects will undergo an fMRI scanning before the first and after the last psilocybin session.
After no official human research in the last 40 years, research and therapeutic uses of the serotonergic psychedelic lysergic acid diethylamide (LSD) are now re-recognized and include its use in brain research, alcoholism, anxiety associated with a terminal illness, and treatment of headache disorders. Specifically, LSD has been reported to abort attacks, decrease the frequency and intensity of attacks, and induce remission in patients suffering from cluster headaches (CH).
The purpose of this study is to investigate the effects of an oral psilocybin pulse regimen in cluster headache. Subjects will be randomized to receive oral placebo, low dose psilocybin, or high dose psilocybin in three experimental sessions, each separated by 5 days.
Start date: 2016-11-1
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Browse through all psychedelic trials that have been done or are ongoing. These trials, usually double-blind, placebo-controlled studies, are the core of psychedelic research. The outcome of these trials will determine the future of psychedelics as medicine.
The trials included in our database come from ClinicalTrials.Gov and from the various companies pursuing psychedelics as medicine. Most of the trials have been funded by universities, though companies and governments are currently starting to ramp up their involvement.