Repeat Dosing of Psilocybin in Migraine Headache

In seeking to understand the capacity for psilocybin to reduce migraine headache burden, this study will investigate single and repeated dosing of psilocybin up to two doses. In seeking to identify an underlying mechanism in psilocybin’s effects, neuroinflammatory markers for migraine headache will be measured.

Topic Headache Disorders Pain
Compound Placebo Psilocybin
Country China
Visit trial
Status Not yet recruiting
Results Published No
Start date 15 July 2021
End date 15 July 2023
Chance of happening 90%
Phase Phase I
Design Blinded
Type Interventional
Generation First
Participants 24
Sex All
Age 21- 65
Therapy No

Trial Details

Migraine headache is a common medical condition and a top cause of disability worldwide. Treatment options for migraine headache are many and varied, though an approximated 10% of migraineurs is refractory to medication and thus, there is a need to develop alternative treatments. There is anecdotal evidence supporting lasting therapeutic effects after limited dosing of psilocybin and related compounds in headache disorders. The cause of this unique effect remains unknown, though the drug class has demonstrable anti-inflammatory activity, a biological process relevant to migraine and other headache disorders. In seeking to understand the capacity for psilocybin to reduce migraine headache burden, this study will investigate single and repeated dosing of psilocybin up to two doses. In seeking to identify an underlying mechanism in psilocybin's effects, neuroinflammatory markers for migraine headache will be measured. The results from this study will serve in the development of larger investigations seeking to understand the effects of psilocybin and related compounds in headache disorders.

NCT Number NCT04218539

Measures Used

5-Dimensional Altered States of Consciousness Questionnaire
The 5D-ASC scale measures altered states of consciousness and contains 94 items (visual analog scales).

Data attribution

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