This double-blind, placebo-controlled study (n=75) found that two high dosages (20 & 30mg/70kg) of psilocybin in combination with spiritual practice showed significant positive (and enduring) effects over that of spiritual practice alone. This effect was even more pronounced on various measures when more support (high support) was given to those on the high (non-placebo) dose.
Abstract of Psilocybin-occasioned mystical-type experience in combination with meditation
“Psilocybin can occasion mystical-type experiences with participant-attributed increases in well-being. However, little research has examined enduring changes in traits. This study administered psilocybin to participants who undertook a program of meditation/spiritual practices. Healthy participants were randomized to three groups (25 each): (1) very low-dose (1 mg/70 kg on sessions 1 and 2) with moderate-level (“standard”) support for spiritual-practice (LD-SS); (2) high-dose (20 and 30 mg/70 kg on sessions 1 and 2, respectively) with standard support (HD-SS); and (3) high-dose (20 and 30 mg/70kg on sessions 1 and 2, respectively) with high support for spiritual practice (HD-HS). Psilocybin was administered double-blind and instructions to participants/staff minimized expectancy confounds. Psilocybin was administered 1 and 2 months after spiritual-practice initiation. Outcomes at 6 months included rates of spiritual practice and persisting effects of psilocybin. Compared with low-dose, high-dose psilocybin produced greater acute and persisting effects. At 6 months, compared with LD-SS, both high-dose groups showed large significant positive changes on longitudinal measures of interpersonal closeness, gratitude, life meaning/purpose, forgiveness, death transcendence, daily spiritual experiences, religious faith and coping, and community observer ratings. Determinants of enduring effects were psilocybin-occasioned mystical-type experience and rates of meditation/spiritual practices. Psilocybin can occasion enduring trait-level increases in prosocial attitudes/behaviors and in healthy psychological functioning.“
Authors: Roland R. Griffiths, Matthew W. Johnson, William A. Richards, Brian D. Richards, Robert Jesse, Katherine A. MacLean, Frederick S. Barrett, Mary P. Cosimano & Maggie A. Klinedinst
Summary of Psilocybin-occasioned mystical-type experience in combination with meditation
Quantum change experiences are sudden, distinctive, benevolent, and often profoundly meaningful experiences that are said to result in personal transformations. They have been variously labeled as mystical experiences, conversion experiences, religious experiences, peak experiences, transcendental experiences, transforming moments, or epiphanies.
Psilocybin, a classic psychedelic, can occasion deeply personally meaningful and often spiritually significant experiences in healthy volunteers. Although these experiences are often attributed to enduring positive changes in well-being and worldview, there is little evidence that psilocybin produces enduring changes on well-validated trait measures of disposition or personality.
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https://doi.org/10.1177/0269881117731279
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Cite this paper (APA)
Griffiths, R. R., Johnson, M. W., Richards, W. A., Richards, B. D., Jesse, R., MacLean, K. A., ... & Klinedinst, M. A. (2018). Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors. Journal of psychopharmacology, 32(1), 49-69.
Study details
Compounds studied
Psilocybin
Topics studied
Healthy Subjects
Study characteristics
Original
Placebo-Controlled
Active Placebo
Double-Blind
Randomized
Participants
75
Humans
Institutes
Institutes associated with this publication
Johns Hopkins UniversityJohns Hopkins University (Medicine) is host to the Center for Psychedelic and Consciousness Research, which is one of the leading research institutes into psychedelics. The center is led by Roland Griffiths and Matthew Johnson.
Compound Details
The psychedelics given at which dose and how many times
Psilocybin 20 - 30mg | 2x
Linked Clinical Trial
Psilocybin and Spiritual PracticeThis study will investigate the effects of psilocybin dose and the frequency and intensity of support activities for spiritual practice (e.g., meditation) on a battery of attitudinal and behavioral outcome measures in 75 healthy volunteers who are interested in pursuing a program of spiritual practices with the intention applying spiritual insights and knowledge to everyday life.