This study designed an infusion protocol for DMT using pharmacokinetic/pharmacodynamic modelling. Comparing a continuous variable model to two bounded integer models, optimal doses for desired psychedelic intensity were identified. However, achieving consistent target intensity was challenging across models, indicating individual dose adjustments might be needed. Differences between models were especially notable at the scale’s boundaries.
Abstract of Optimized infusion rates for DMT to achieve a target psychedelic intensity
Authors: Emma Eckernäs, Jeroen Koomen, Christopher Timmermann, Robin L. Carhart-Harris, Daniel Röshammar & Michael Ashton
Summary of Optimized infusion rates for DMT to achieve a target psychedelic intensity
The need for new treatments for psychiatric disorders has led to increased research on different psychedelic compounds. The subjective psychedelic experience may be closely related to therapeutic effects.
The relationship between exposure to the psychedelic compound DMT and its psychedelic effects has previously been investigated using population pharmacokinetic/pharmacodynamic modelling. A continuous infusion of DMT over varying lengths of time has been proposed as a suitable way to extend the psychedelic experience.
The subjective intensity score used in the aforementioned study is a discrete outcome variable that can only assume integer values within certain boundaries. A bounded integer model can better fit the data than a continuous variable model.
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Eckernäs, E., Koomen, J., Timmermann, C., Carhart‐Harris, R., Röshammar, D., & Ashton, M. (2023). Optimized infusion rates for N, N‐dimethyltryptamine to achieve a target psychedelic intensity based on a modeling and simulation framework. CPT: Pharmacometrics & Systems Pharmacology.