Effective Connectivity of LSD-induced Ego Dissolution

This preprint (2022) used fMRI to assess whether anticorrelated activity between the default mode network (DMN) and the salience network (SN), which recruits the dorsal attention network (DAN), underlie the peak effects of LSD (n=25). It was found that LSD (100 mg) decreased inhibitory effective connectivity from the SN to DMN as well as decreasing inhibitory effective connectivity from DMN to DAN when compared to placebo. These findings suggest anticorrelation between resting networks may be a key neural mechanism of LSD peak experiences.

Abstract

“Classic psychedelic-induced ego dissolution involves a shift in the sense of self and blurring of the boundary between the self and the world. A similar phenomenon is identified in psychopathology and is associated with the balance of anticorrelated activity between the default mode network (DMN), which directs attention inwards, and the salience network (SN), which recruits the dorsal attention network (DAN) to direct attention outward. To test whether a change in anticorrelated networks underlies the peak effects of LSD, we applied dynamic causal modelling to infer (directed) effective connectivity of resting-state functional MRI scans from a double-blind, randomised, placebo-controlled cross-over study where 100mg of LSD, or placebo, was administered to 25 healthy adults. Under the peak effects of LSD, the hierarchical organisation of the resting-state brain networks was altered. Inhibitory effective connectivity from the SN to DMN decreased and became excitatory, and inhibitory effective connectivity from DMN to DAN decreased when compared to the placebo. These changes in connectivity reflect diminution of the anticorrelation between the resting state networks which may be a key neural mechanism of LSD-induced ego dissolution. Our findings suggest the hierarchically organised balance of resting-state networks is a central feature in the construct of self.”

Authors: Devon Stoliker, Leonardo Novelli, Franz X. Vollenweider, Gary Egan, Katrin Preller & Adeel Razi

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Effective Connectivity of LSD-induced Ego Dissolution

https://doi.org/10.1101/2021.12.28.21268391

Open Access | Google Scholar | Backup | 🕊

Published in
MedRvix
January 3, 2022
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Study details

Compounds studied
LSD

Participants
25 Humans

Authors

Authors associated with this publication with profiles on Blossom

Franz Vollenweider
Franz X. Vollenweider is one of the pioneering psychedelics researchers, currently at the University of Zurich. He is also the director of the Heffter (sponsored) Research Center Zürich for Consciousness Studies (HRC-ZH).

Institutes

Institutes associated with this publication

University of Basel
The University of Basel Department of Biomedicine hosts the Liechti Lab research group, headed by Matthias Liechti.

Compound Details

The psychedelics given at which dose and how many times

LSD 100 μg

Linked Clinical Trial

The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers
Aim of the present study is to investigate the neuronal correlates of self and of personal meaning as well as the role of the serotonin (5-HT) 2A receptor system in these processes using functional magnetic resonance imaging (fMRI) and psychometric and cognitive measures.

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