Persisting Effects of Psilocybin

The proposed pilot study will assess whether ingestion of a classic hallucinogen (psilocybin) leads to changes in emotion processing and neural circuitry that may predict repeated self-administration of this drug and underlie an atypical mechanism of abuse liability, which may vitally contribute to the understanding of the potential for abuse and the underlying mechanisms supporting abuse of classic hallucinogens.

Topic Healthy Subjects
Compound Psilocybin
Country United States of America
Visit trial
Status Completed
Results Published Yes
Start date 01 July 2017
End date 27 August 2018
Chance of happening 100%
Phase Phase I Phase II
Design Open
Type Interventional
Generation First
Participants 13
Sex All
Age 18- 45
Therapy No

Trial Details

The proposed pilot study will assess whether ingestion of a classic hallucinogen (psilocybin) leads to changes in emotion processing and neural circuitry that may predict repeated self-administration of this drug and underlie an atypical mechanism of abuse liability, which may vitally contribute to the understanding of the potential for abuse and the underlying mechanisms supporting abuse of classic hallucinogens.

NCT Number NCT02971605

Sponsors & Collaborators

Johns Hopkins University
Johns Hopkins University (Medicine) is host to the Center for Psychedelic and Consciousness Research, which is one of the leading research institutes into psychedelics. The center is led by Roland Griffiths and Matthew Johnson.

National Institute on Drug Abuse
This company doesn't have a full profile yet, it is linked to a clinical trial.

Papers

Emotions and brain function are altered up to one month after a single high dose of psilocybin
This open-label (n=12) study investigated brain function (increased plasticity) and positive and negative affect. After a high dose of psilocybin (25mg/70kg), the positive effect increased and stayed elevated. Negative effects returned to normal at 1-month.

Data attribution

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