Mood Effects of Serotonin Agonists Extended

This triple-blind, randomized, crossover trial (n=80) aims to investigate the effects of repeated very low doses of serotonin agonists on individuals with negative mood. This trial, sponsored by the University of Chicago, utilized a serotonin agonist, specifically 13ug of lysergic acid diethylamide (LSD), and a placebo for comparison. The participants’ mood states were measured using the Profile of Mood States (POMS), a validated scale that assesses positive and negative mood states. The trial commenced on April 20, 2019, and was completed on June 7, 2021.

Topic Healthy Subjects
Compound Placebo LSD
Country United States of America
Visit trial
Status Completed
Results Published No
Start date 20 April 2019
End date 07 June 2021
Chance of happening 100%
Phase Phase I
Design Blinded
Type Interventional
Generation First
Participants 80
Sex All
Age 18- 40
Therapy No

Trial Details

In this study we are examining the effects of repeated very low doses of serotonin agonists on mood individuals with negative mood.

NCT Number NCT03934710

Sponsors & Collaborators

University of Chicago
Research with psychedelics is taking place at the Human Behavioral Pharmacology Lab at the University of Chicago.

Data attribution

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