University of Iowa Interventional Psychiatry Service Patient Registry

The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion and intranasal esketamine insufflation.

The investigators will obtain various indicators, or biomarkers, of a depressed individuals’ state before, during, and/or after these treatments. Such biomarkers include neurobehavioral testing, neuroimaging, electroencephalography, cognitive testing, vocal recordings, epi/genetic testing, and autonomic nervous system measures (i.e. “fight-or-flight” response).

The results obtained from this study may provide novel antidepressant treatment response biomarkers, with the future goal of targeting a given treatment to an individual patient (“personalized medicine”).

Topic Treatment-Resistant Depression
Compound Ketamine
Country United States of America
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Trial Details



Trial Number

Sponsors & Collaborators

University of Iowa
The Niciu Lab at the University of Iowa is interested in the therapeutic effects of ketamine.

Measures Used

Montgomery-Asberg Depression Rating Scale
A ten-item diagnostic questionnaire used to measure the severity of depressive symptoms in patients with mood disorders.

Data attribution

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