Testing the Effectiveness of Cognitive Training Among Depressed Patients Receiving Esketamine Treatment

This treatment trial (n=40) aims to enhance depression relief among patients already undergoing esketamine treatment by introducing computer-based cognitive training.

The University of Pittsburgh is conducting the study to test whether this adjunctive intervention can improve depression outcomes. Participants aged 18 to 80 will be randomly assigned to receive either cognitive training or sham training over eight web-based sessions.

The primary outcome measures include depression severity, assessed by the Montgomery Asberg Depression Rating Scale, and self-reported depression symptoms, measured by the Quick Inventory of Depressive Symptoms.

Secondary outcomes include clinician-rated depression, clinical global impression scales, and measures of treatment satisfaction. The study started on February 14, 2023, and is estimated to complete by August 1, 2025.

Topic Depression
Compound Ketamine
Country United States of America
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University of Pittsburgh
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