Study of Depression-Ketamine-Brain Function

Targeting the glutamatergic system to treat depression is a new and promising strategy based on studies at the molecular, synaptic, and neuronal level but also on results of studies conducted in animal models and first clinical studies involving depressed patients.

Ketamine has been proposed as a novel approach to induce rapid antidepressant response. In this pilot project the investigators aim to introduce this novel and promising approach into clinical practice.

Besides the assessment of clinical efficacy, the investigators will put a special emphasis on the assessment of ketamine-associated effects on brain function using fMRI and cognitive testing.

Topic Depression
Compound Ketamine
Country Switzerland
Visit trial
Status Terminated
Results Published
Start date 06 January 2010
End date 09 January 2015
Phase Phase II
Design Open
Type Interventional
Generation First
Participants 10
Sex All
Age 18- 65
Therapy No

Trial Details

Targeting the glutamatergic system to treat depression is a new and promising strategy based on studies at the molecular, synaptic, and neuronal level but also on results of studies conducted in animal models and first clinical studies involving depressed patients.Ketamine has been proposed as a novel approach to induce rapid antidepressant response. In this pilot project the investigators aim to introduce this novel and promising approach into clinical practice. Besides the assessment of clinical efficacy, the investigators will put a special emphasis on the assessment of ketamine-associated effects on brain function using fMRI and cognitive testing.

Trial Number NCT01135758

Sponsors & Collaborators

University Hospital Geneva
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Data attribution

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