Spreading Depolarization and Ketamine Suppression

To demonstrate, in a group of patients with acute severe brain injury requiring surgery including traumatic brain injury and aneurysmal subarachnoid hemorrhage, whether use of continuous infusion of ketamine decreases frequency of occurrence of cortical spreading depolarizations.

Compound Placebo Ketamine
Country United States of America
Visit trial
Status Completed
Results Published
Start date 07 January 2015
End date 05 January 2017
Chance of happening 100%
Phase Phase I
Design Blinded
Type Interventional
Generation First
Participants 10
Sex All
Age 18- 90
Therapy No

Trial Details

Hypothesis: Cortical spreading depolarizations are inhibited by the NMDA receptor antagonist Ketamine Aim 1: To demonstrate, in a group of patients with acute severe brain injury requiring surgery including traumatic brain injury and aneurysmal subarachnoid hemorrhage, whether use of continuous infusion of ketamine decreases frequency of occurrence of cortical spreading depolarizations.

NCT Number NCT02501941

Sponsors & Collaborators

University of New Mexico
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Data attribution

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