Reward Emotion Learning and Ketamine Study

This study will help the investigators to understand the basis of ketamine’s antidepressant effects and aid the development of new treatments for depression.

Topic Depression Treatment-Resistant Depression
Compound Placebo Ketamine
Country United Kingdom
Visit trial
Status Not yet recruiting
Results Published
Start date 04 January 2021
End date 11 January 2022
Phase Not Applicable
Design Blinded
Type Interventional
Generation First
Participants 35
Sex All
Age 18- 45
Therapy No

Trial Details

Ketamine's efficacy as an antidepressant is now well established yet the mechanisms underlying its antidepressant effect are yet to be fully described. Work in the animal literature and research in humans is suggestive of specific effects on anhedonia and memory reconsolidation. In this study the investigators will further explore the effects of ketamine on learning and memory as well as measuring the associated changes at neural level in a sample of healthy volunteers. Participants will be assigned to receive ketamine or placebo and complete a set of tasks which will allow the investigators to quantify the effect of ketamine on learning about reward and punishment and memory for learned reward associations 24 hours after ketamine infusion. This study will help the investigators to understand the basis of ketamine's antidepressant effects and aid the development of new treatments for depression.

Trial Number NCT04850911

Sponsors & Collaborators

University of Oxford
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Data attribution

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