Low-Dose Intravenous Ketamine for Adolescents With Depression and Suicidal Ideation in the Emergency Department

This early Phase I interventional trial (n=30) aims to investigate the effectiveness of a single low-dose intravenous ketamine administered in the emergency department for adolescents with treatment-resistant depression (TRD) and suicidal ideation (SI).

Conducted by Rady Children’s Hospital in San Diego, California, the study involves adolescents aged 12 to 18 who require inpatient psychiatric admission and have treatment-resistant depression. Participants will be randomly assigned to receive either ketamine or a placebo.

The primary outcome measure is the change in the Beck Depression Inventory Depression sub-scale score, assessed at multiple time points over 7 days post-treatment. Secondary outcome measures include changes in anxiety and self-concept sub-scale scores, as well as suicidal ideation scores.

The study aims to provide insights into the potential benefits of low-dose ketamine in managing depression and suicidal thoughts in adolescents presenting to the emergency department.

Topic Treatment-Resistant Depression Suicidality Depression
Compound Placebo Ketamine
Country United States of America
Visit trial
Status Recruiting
Results Published No
Start date 01 March 2022
End date 01 January 2024
Phase Phase I
Design Blinded
Type Interventional
Generation First
Participants 30
Sex All
Age 12- 18
Therapy No

Trial Details

The goal of this study is to test whether a single low-dose of IV ketamine given in the emergency department to adolescents with treatment-resistant depression and suicidal ideation can reduce depression symptoms and suicidal thoughts compared to placebo. Participants will complete depression scales at baseline, and 1 hour, 3 hours, 1 day, 3 days, and 7 days after receiving the treatment.

NCT Number NCT05217706

Data attribution

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