This study will explore whether the use of a medication, ketamine, can help patients who come to the ER with thoughts of suicide by improving their mood and reducing thoughts of suicide.
Ketamine has been used for this purpose in patients who have been hospitalized, but it has not been well studied in the ER. The investigators are first trying to show that patients and doctors in the ER find the treatment acceptable.
The investigators also hope to determine whether ketamine is effective in decreasing the severity of patient’s suicidal thinking while in the ER. If this treatment works, future studies will look at whether it can help patients be discharged from the hospital earlier.
Topic Depression
Suicidality
Compound Ketamine
Country United States of America
Visit trial
Status
Completed
Results Published
Start date
01 July 2019
End date
31 December 2021
Chance of happening
100%
Phase
Phase I
Design
Open
Type
Interventional
Generation
First
Participants
20
Sex
All
Age
18- 65
Therapy
No
Trial Details
Mood disorders complicated by suicidal ideation (SI) are common among patients presenting to the Emergency Department (ED). Under current standard practice, patients awaiting psychiatric evaluation in the emergency department do not typically receive interventions to address their mood disorder or SI. With no end to the extended ED boarding of psychiatric patients in sight, improvements in the acute treatment of SI with ketamine may help more patients receive prompt and appropriate treatment. Low-dose ketamine has been well studied in psychiatric literature. Studies involving a single dose of ketamine are promising, demonstrating both immediate and sustained reductions in suicidal ideations. Low dose ketamine has been well-studied in the ED for pain, asthma, and agitation, but not mood disorders or SI. This study aims to determine whether or not it is feasible to administer low dose ketamine in the emergency department for the management of mood disorders with SI. Feasibility of ketamine administration in the ED and will be determined by: (1) ability to recruit participants, (2) tolerability of the intervention, and (3) acceptability by patients/providers. The investigators will also explore whether the administration of ketamine results in improvements in mood and SI. This prospective open label feasibility pilot study will enroll 20 participants to receive ketamine at 0.5mg/kg infused intravenously over 40 minutes. Patients that have active suicidal ideation as determined by psychiatry staff who are being admitted to psychiatry under voluntary certification will be eligible for the study. The investigators will assess self-reported mood and suicidal ideations pre- and post-infusion of ketamine. Participants will complete assessments at baseline (pre-infusion), 2 hours and 6 hours post-infusion, and daily while in the ED until inpatient disposition. The investigators hypothesize ketamine administration will be feasible in the emergency department and will result in improved mood and decreased SI.NCT Number NCT04099771
Sponsors & Collaborators
The Miriam HospitalThis company doesn't have a full profile yet, it is linked to a clinical trial.
Papers
A feasibility study of low-dose ketamine for acute management of suicidal ideationThis open-label study (n=14) finds that ketamine (35mg/70kg) infusion significantly reduced suicidal ideation (SI) in patients in the emergency department (ED). The acceptability (willingness to try treatment) was also high (>70%) among patients and physicians. The study is the first to test this in the ED.