Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine

This early Phase I interventional trial (n=250) conducted by Emory University aims to investigate the effects of ketamine on decision-making and emotion processing in individuals diagnosed with Major Depressive Disorder (MDD).

The study focuses on understanding ketamine’s impact on various functional aspects of depression, including anhedonia, decision-making, and emotion processing. It involves administering sub-anesthetic doses of ketamine and using questionnaires, neuroimaging techniques, and behavioral tasks to assess its effects. The trial includes MDD patients who will receive ketamine or placebo and healthy controls who will undergo assessments without intervention.

Primary outcomes include evaluating the glutamate stress response, while secondary outcomes encompass various psychological and cognitive measures. The study utilises a triple masking approach and involves randomisation. Recruitment began in November 2022 and is expected to continue until November 2026.

Topic Depression
Compound Ketamine
Country United States of America
Visit trial
Status Recruiting
Results Published No
Start date 08 November 2022
End date 31 December 2026
Phase Phase I
Design Blinded
Type Interventional
Generation First
Participants 250
Sex All
Age 18- 65
Therapy No

Trial Details

The main purpose of this study is to investigate the effects of ketamine on decision-making and emotion processing in a sample of individuals diagnosed with Major Depressive Disorder (MDD).

NCT Number NCT05327699

Sponsors & Collaborators

Emory University
Emory University has recently launched the Center for Psychedelics and Spirituality (ECPS). The centre will combine expertise in psychiatry with spiritual health to better understand the therapeutic promise of psychedelics as medicine.

Data attribution

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