Effects of Subanesthetic Dose of Ketamine Given on Postoperative Mood in Patients Undergoing Fractional Curettage

This randomized controlled trial (n=140) investigated the impact of a single subanesthetic dose of ketamine (35mg/70kg) administered intravenously during the induction of propofol/fentanyl anesthesia on acute mood states in women undergoing fractional curettage.

The study aimed to determine if administering 0.5 mg/kg of ketamine had an effect on mood compared to a control group receiving saline. Participants were women aged 18 to 75 undergoing fractional curettage, excluding those with certain medical conditions or history of psychological disorders.

After obtaining informed consent, participants were randomly assigned to either the ketamine or control group. Mood was assessed using the Profile of Mood States (POMS) questionnaire before and after surgery. Secondary outcomes included pain assessment, blood pressure, heart rate, sedation levels, and adverse events.

The study was conducted at Istanbul Training and Research Hospital in Turkey from April 2022 to September 2022.

Compound Placebo Ketamine
Country Turkey
Visit trial
Status Completed
Results Published No
Start date 01 April 2022
End date 01 September 2022
Phase Phase IV
Design Blinded
Type Interventional
Generation First
Participants 140
Sex Female
Age 18- 75
Therapy No

Trial Details

When given intravenously in doses below 1.2mg/kg, ketamine has been shown to work as an antidepressant. Ketamine is a common induction drug used during general anesthesia. It is known to reduce postoperative pain in this instance. Limited studies have evaluated the effect of a single subanesthetic dosage of ketamine administered as an adjunct to general anesthesia on acute mood states in patients undergoing minor surgery. The aim of this randomized controlled study was to examine if a single intravenous administration of 0.5 mg/kg ketamine given at the induction of propofol/fentanyl anesthesia has an effect on acute mood states before the discharge of women undergoing fractional curettage.

NCT Number NCT05752110

Data attribution

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