Effects of Subanesthetic Dose of Ketamine Given on Postoperative Mood in Patients Undergoing Fractional Curettage

This randomized controlled trial (n=140) investigated the impact of a single subanesthetic dose of ketamine (35mg/70kg) administered intravenously during the induction of propofol/fentanyl anesthesia on acute mood states in women undergoing fractional curettage.

The study aimed to determine if administering 0.5 mg/kg of ketamine had an effect on mood compared to a control group receiving saline. Participants were women aged 18 to 75 undergoing fractional curettage, excluding those with certain medical conditions or history of psychological disorders.

After obtaining informed consent, participants were randomly assigned to either the ketamine or control group. Mood was assessed using the Profile of Mood States (POMS) questionnaire before and after surgery. Secondary outcomes included pain assessment, blood pressure, heart rate, sedation levels, and adverse events.

The study was conducted at Istanbul Training and Research Hospital in Turkey from April 2022 to September 2022.

Compound Placebo Ketamine
Country Turkey
Visit trial

Trial Details



Trial Number

Data attribution

A large set of the trials in our database are sourced from ClinicalTrials.gov (CTG). We have modified these post to display the information in a more clear format or to correct spelling mistakes. Our database in actively updated and may show a different status (e.g. completed) if we have knowledge of this update (e.g. a published paper on the study) which isn't reflected yet on CTG. If a trial is not sourced from CTG, this is indicated on this page and you can follow the link to the alternative source of information.