A Study to Assess Feasibility of Using Clinician-directed and Digital Application Supported Cognitive Behavior Therapy (CBT) in Conjunction With Esketamine in Participants With Treatment-resistant Depression

This feasibility study (n=0, withdrawn) aimed to assess the combination of clinician-directed cognitive behavioural therapy (CBT) supplemented with the Mindset app alongside esketamine therapy in individuals with treatment-resistant depression.

The trial, sponsored by Janssen Research & Development, LLC, explored the potential of this combined approach to addressing depression. It was set to take place at various locations in the United States, including Yale University, Rush University Medical Center, the University of Chicago, Sheppard Pratt Health System, and the University of Cincinnati.

Unfortunately, the study was withdrawn due to budget constraints and a shift in research priorities away from this investigation.

Topic Treatment-Resistant Depression Depression
Compound Ketamine
Country United States of America
Visit trial
Status Withdrawn
Results Published No
Start date 01 September 2022
End date 07 June 2023
Phase Phase I
Design Open
Type Interventional
Generation Second
Participants 0
Sex All
Age 18- 65
Therapy Yes

Trial Details

The purpose of this study is to explore feasibility of combining clinician-directed cognitive behavioral therapy (CBT) supplemented with the Mindset app with esketamine therapy in participants with Treatment-resistant Depression.

NCT Number NCT05268497

Sponsors & Collaborators

Johnson & Johnson
One of the largest pharmaceutical companies in the world, Johnson & Johnson are responsible for bringing esketamine to market in the form of Spravato.

Data attribution

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