[11C]-(R)-Rolipram to Measure cAMP Signaling Before and After Ketamine

This interventional trial (n=0, terminated) aimed to measure the effects of ketamine infusion on cAMP signalling in the human brain to ascertain if ketamine contributes to its antidepressant effects by modulating cAMP levels.

Participants, aged 18 to 70, diagnosed with Major Depressive Disorder (MDD), enrolled in other NIH studies involving ketamine. They underwent PET scans and MRI to assess brain activity before and after ketamine administration.

The primary objective was to determine if ketamine increased cAMP signalling, while secondary objectives included correlating cAMP increases with symptomatic improvements in depression.

The study was terminated due to low recruitment.

Topic Depression Neuroscience
Compound Ketamine
Country United States of America
Visit trial
Status Terminated
Results Published Yes
Start date 08 February 2023
End date 30 January 2024
Phase Phase I
Design Open
Type Interventional
Generation First
Participants 0
Sex All
Age 18- 70
Therapy No

Trial Details

This study aims to investigate whether administering ketamine to individuals with major depressive disorder (MDD) influences the levels of cyclic AMP (cAMP) in their brains. Eligible participants, aged 18 to 70, enrolled in another NIH study involving ketamine, will visit the NIH clinic up to 5 times over a span of 6 weeks. Screening will involve physical exams, blood and urine tests, heart function tests, and psychiatric evaluations. Participants will undergo positron emission tomography (PET) scans before and after receiving ketamine, along with magnetic resonance imaging (MRI). These scans will assess brain activity and cAMP levels.

Trial Number NCT05522673

Sponsors & Collaborators

National Institute of Mental Health
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Data attribution

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