This review (1998) looks at the history of LSD as a possible treatment for alcoholism (AUD). It highlights the research that had been done and how psychedelics were subsequently relabelled as drugs of abuse.
Abstract of Treatment of alcoholism using psychedelic drugs
“Following Albert Hofmann‘s discovery of LSD’s psychoactive properties in 1943, and previous to their scheduling as controlled substances, the psychedelic drugs were widely studied – six international conferences and hundreds of papers discussed their potential therapeutic usefulness. The observation that the frightening experience of delirium tremens sometimes led alcoholics to moderate their alcohol intake suggested to early psychedelic researchers that the “psychotomimetic” experience thought to be produced by LSD could be used to treat alcoholism. A number of hypothesis-generating studies employing a variety of research designs to examine this premise were completed, but relatively few controlled trials attempted hypothesis testing. After twenty-five years of study, a combination of flawed methodology, uneven results and social reprehension led to the abandonment of research on the therapeutic use of psychedelic drugs, leaving many avenues of inquiry unexplored and many questions unanswered. Today, after a thirty-year hiatus, this research is gradually being resumed, and there is renewed interest in the findings of previous studies. This article explores the history of one branch of psychedelic research, the therapeutic use of LSD in the treatment of alcoholism, and of the events that led to the relabeling of the “hallucinogens” as drugs of abuse.”
Author: Mariavittoria Mangini
Summary of Treatment of alcoholism using psychedelic drugs
Smith’s report described a pilot study of LSD and mescaline treatment of “particularly refractory alcoholics”, who had been diagnosed with character disorder, psychopathy, borderline or actual psychoses, and concomitant use of drugs other than alcohol.
Smith addressed the importance of follow-up in estimating the effectiveness of new treatment, and noted that patients can relapse after being helped by the treatment.
Smith’s follow-up report on the pilot study reiterated his original conclusion that the results were encouraging enough to warrant more extensive and controlled trials.
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Mangini, M. (1998). Treatment of alcoholism using psychedelic drugs: a review of the program of research. Journal of psychoactive drugs, 30(4), 381-418.