Psychedelics and mental health: a population study

This survey study that included psychedelics users (n=21.967, 13% of total) found no associations between psychedelics use and mental health outcomes. It even found a slightly lower rate of mental health problems for those who used psychedelics.


“Background The classical serotonergic psychedelics LSD, psilocybin, mescaline are not known to cause brain damage and are regarded as non-addictive. Clinical studies do not suggest that psychedelics cause long-term mental health problems. Psychedelics have been used in the Americas for thousands of years. Over 30 million people currently living in the US have used LSD, psilocybin, or mescaline.

Objective To evaluate the association between the lifetime use of psychedelics and current mental health in the adult population.

Method Data drawn from years 2001 to 2004 of the National Survey on Drug Use and Health consisted of 130,152 respondents, randomly selected to be representative of the adult population in the United States. Standardized screening measures for past-year mental health included serious psychological distress (K6 scale), mental health treatment (inpatient, outpatient, medication, needed but did not receive), symptoms of eight psychiatric disorders (panic disorder, major depressive episode, mania, social phobia, general anxiety disorder, agoraphobia, posttraumatic stress disorder, and non-affective psychosis), and seven specific symptoms of non-affective psychosis. We calculated weighted odds ratios by multivariate logistic regression controlling for a range of sociodemographic variables, the use of illicit drugs, risk-taking behavior, and exposure to traumatic events.

Results 21,967 respondents (13.4% weighted) reported lifetime psychedelic use. There were no significant associations between lifetime use of any psychedelics, lifetime use of specific psychedelics (LSD, psilocybin, mescaline, peyote), or past year use of LSD and increased rate of any of the mental health outcomes. Rather, in several cases psychedelic use was associated with a lower rate of mental health problems. Conclusion We did not find the use of psychedelics to be an independent risk factor for mental health problems.

Authors: Teri S. Krebs & Pål-Ørjan Johansen


This study is followed up by another survey by Johansen & Krebs (2015) that found similar results.

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Psychedelics and mental health: a population study

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Published in
August 19, 2013
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